- The interplay between MYC and HIF in cancer – Nature
The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-tumorigenic conditions provides insights into normal homeostatic cellular responses to low oxygen levels…
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation – PubMed
The ability of cells to grow during hypoxia results in part from crosstalk between hypoxia-inducible factors (HIFs) and the proto-oncogene c-Myc. Acting alone, HIF and c-Myc partially regulate complex …
Molecular Crosstalk Between MYC and HIF in Cancer – PMC
HIF mediates the primary transcriptional response of a wide range of genes in response to hypoxia. Earlier studies focused on the inhibition of MYC by HIF during hypoxia, when MYC is expressed at phys …
Carrot and stick: HIF-α engages c-Myc in hypoxic adaptation | Cell Death & Differentiation – Nature
This article focuses on the intricate roles of c-Myc in the hypoxic response, discusses various mechanisms controlling c-Myc activity by HIF-α for the regulation of hypoxia-responsive genes,…
C-MYC与HIF-1α在肿瘤发病机制中的作用 – 国际输血及血液学杂志
原癌基因C-MYC可以诱导细胞进入细胞周期,抑制细胞分化及诱导细胞凋亡；而缺氧诱导因子-1α (HIF-1α)促进肿瘤血管的生成,促进肿瘤细胞的能量代谢,促进红细胞生成,诱导肿瘤细胞浸润和转移.C-MYC与HIF-1在恶性肿瘤的发生、发展和预后评估上有着重要意义,近期研究 … …
ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1
Hypoxia-inducible factor 1-α (HIF-1α) and MYC are transcription factors that induce the expression of genes essential for cancer progression. Here, we report that HIF-1α and MYC are both indirectly ta …
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation – PubMed Central (PMC)
In this review, we summarize the effects of c-Myc and HIFs on carbon metabolism, protein synthesis, and proliferation, highlighting their antagonist effects on carbon utilization and translation initi …
A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways – PubMed Central (PMC)
In this review, we summarize the role of deregulated c-Myc and HIF in tumorigenesis in general, and MM in particular. Moreover, we focus on the proposed key pathophysiologic role of deregulated c-Myc- …
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation: Cancer Cell
The ability of cells to grow during hypoxia results in part from crosstalk between hypoxia-inducible factors (HIFs) and the proto-oncogene c-Myc. Acting alone, HIF and c-Myc partially regulate complex …
The interplay between MYC and HIF in the Warburg effect
c-MYC and the hypoxia-inducible factors (HIFs) are critical factors for tumorigenesis in a large number of human cancers. While the normal function of MYC involves the induction of cell proliferation …
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